EU-OPENSCREEN ERIC Newsletter No 22, June 2021
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EU-OPENSCREEN ERIC - June 2021
HIGHLIGHTS
Discover EU-OPENSCREEN´s services: New Image Video online
Do not miss to watch our new EU-OPENSCREEN image video. The short sequence gives you valuable insights into our work and shows you how you can benefit from our services. We will take you along on our journey to discover the secrets of life and to develop novel drugs to fight the grand societal challenges.


Get to know our partner sites selected based on scientific excellence

EU-OPENSCREEN partner sites are leading experts in the field of chemical biology and early drug discovery in Europe. The selection of our partner sites follows a rigorous three-step procedure, which emphasises scientific excellence and technical capabilities to support user projects.

Our partner sites provide chemical biology related services including assay development, assay adaptation, screening, and medicinal chemistry (including compound design, synthesis, analytics and SAR generation). These services are carried out in the member countries. The partner sites are organisationally independent of the EU-OPENSCREEN ERIC and remain embedded in their host institutions.

Get to know our partner sites and see what they can offer for your research project. You will learn about their infrastructure and technical focus, their projects and their scientific track records. Our new partner site brochure is now available as an interactive PDF in our resource center on our website.

Find out about our COVID-19 related services

EU-OPENSCREEN partner sites offer biochemical and cellular assays that include bacterial, viral and human targets. Moreover, partners with a specific research focus on infectious diseases can provide their support in the design and development of phenotypic assays (monitoring of bacterial growth inhibition, viral replication and virus-induced cyto-pathic effects), target-based assays with engineered bacteria or viruses cell-based high-content screening (HCS) assays and host cell response assays all implemented in Biosafety Level (BSL) 2 and 3 laboratories.

Find out more about our COVID-19 related services in our new COVID-19 brochure and on our website.

ECBS 2021 a great success
European Chemical Biology Symposium (ECBS), 26-28 May 2021

We would like to thank all speakers and participants of this year´s ECBS for their great contribution to the first virtual European Chemical Biology Symposium (ECBS). The European Chemical Biology Symposium (ECBS) 2021, which was jointly organised by EU-OPENSCREEN and the EuChemS Division of Chemistry for Life Sciences in May 2021 has been a great success.
 

During the three days scientists from Europe and beyond came together to present and discuss their latest achievements in cutting edge chemical sciences at the interface to biology and medicine, ranging from new therapeutic approaches to resistant pathogens and viral infections (special session on COVID19 research), to targeting protein degradation, natural products, artificial intelligence in drug discovery, nanostructured biomaterials, synthetic biology, glycochemistry and the chemistry of the origin of life.

 
Presentation prizes
 
During the prize ceremony, the 9 best presentations were awarded with 200€ each in the following categories:

1) Organic chemistry interfacing Biology*
2) Innovative hit compounds and biomaterials for drug discovery and development*
3) Innovative approaches in life science*
4) Chemical tools in biology**
5) Chemical glycobiology**
6) Natural products in chemical biology**

*sponsored by the Society of Chemistry of Italy (SCI). Divisions of Organic Chemistry, Medicinal Chemistry and Chemistry in Life Sciences.
**sponsored by the Spanish Royal Society of Chemistry (RSEQ). Divisions of Chemical Biology, Carbohydrates and Natural Products.

Through the Whova conference platform, the best 12 posters were democratically selected by ECBS2021 participants and also rewarded with 100€ each.
 
Further information and downloads

Please visit the event website for more information on the programme and speakers  https://ecbs2021.eu/.

You can also download the Conference books in PDF-Format:

Conference book here

Abstract book here
Save the date for the next ECBS2023 in Scandinavia: www.ecbs2023.eu

Using the EU-OPENSCREEN fragment library: Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
 
Publication Date: April 14, 2021

Fragment-based screening is an approach to identify building blocks of the future drug molecule, observing how they interact with the protein under study, contextualizing those interactions, and providing starting points for molecules that directly influence the biology of the protein. New research published by EU-OPENSCREEN collaborators at the XChem platform at Diamond performed a crystallographic fragment screen of the macrodomain part of the Nsp3 gene product that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. This study discovered 234 fragment compounds that directly bind to sites of interest on the surface of the protein, and that can be used by researchers and pharmaceutical companies to design compounds that could be developed into antiviral drugs.

Link: DOI 10.1126/sciadv.abf8711

45th FEBS Congress
July 3-8, 2021 | Virtual Conference

This year, the annual congress of the Federation of European Biochemical Societies (FEBS) will be a virtual event and is entitled 'Molecules of Life: Towards New Horizons'. Join our EU-OPENSCREEN presentation during the 'Meet the expert session' and visit us at our virtual booth. We share our booth with other research infrastructures in structural biology (Instruct), biological and medical imaging (Euro-BioImaging), and biobanks (BBMRI).

More information: https://2021.febscongress.org/

 
European Symposium on Organic Chemistry (ESOC)
July 5-6, 2021 | Virtual Mini Symposium

Victoria Mora, Analytical Chemist at EU-OPENSCREEN, will give a talk on "OPPORTUNITIES TO IDENTIFY NEW BIOLOGICAL ACTIVITIES OF ACADEMIC COMPOUNDS" at this year´s ESOC virtual mini symposium.

For more information please visit the event website

 

How you can screen your assay with our compound collections
As a biologist with a robust and suitable assay, you are invited to collaboratively develop a chemical tool compound for your target of interest. Your assay will be screened against the whole European Chemical Biology Library (ECBL) in one of our 17 screening facilities across Europe and the data will be made available to the broader scientific community through our open access European Chemical Biology Database (ECBD).

In collaboration with our medicinal chemistry groups, identified active compounds (‘hits’) can be chemically optimised further and translated into valuable tool compounds.

For more information contact our scientific project management team:
E-Mail: scientific-projects@eu-openscreen.eu

How to include your compounds in the European Academic Compound Library (EACL)
Chemists are invited to collaborate with EU-OPENSCREEN by submitting their compounds, free of charge, to the European Academic Compound Library as part of the EU-OPENSCREEN compound libraries collection.

All compounds should be provided with proof of identity (either mass or NMR) and purity. The structure of each compound will undergo computational filters to assess physicochemical properties (i.e., solubility, molecular weight), reactivity and diversity. The complete explanation of the physicochemical properties' assessment can be found here.

Non-compliance with desired standards (for instance, promiscuous binders) will be still accepted as part of the library, but will be “flagged” in order to raise awareness and allow for a rational interpretation of biological results.

The compound will then be bioprofiled, an empirical characterization and annotation of basic physicochemical and “essential to know” biological properties. All results will be part of the ECBD (see above), although will remain for the first six months in the non-publicly disclosed part of the database.

Submitted compounds are then tested in the EU-OPENSCREEN partner network in scientific projects.

If a compound is identified as a hit compound, the chemist will be informed promptly, and a collaboration between assay provider and chemist may start on research projects or on the generation of intellectual property. 

Both parties can ask for an embargo period; if this is not considered, all results will become part of the open access European Chemical Biology Database (ECBD).

For more information on how you can submit your compound to the EU-OPENSCREEN compound library please fill in the expression of interest form on our website https://www.eu-openscreen.eu/compound-submission.html or contact wolfgang.fecke@eu-openscreen.eu.

EU-OPENSCREEN training activities
EU-OPENSCREEN training activities continue during the pandemic. On-line webinars are organised, and expert speakers are invited to give lectures on various scientific topics.

The recorded webinars are uploaded here.

Stay tuned for up-coming training opportunities!

 

If you have any enquiries or suggestions regarding our training courses, please contact:

Dr Kathy Skopelitou (Administrative Project Manager)
Phone: +49 (0)30 9489 2417
E-Mail: training@eu-openscreen.eu
  
CONTACT
General enquiries
Phone: +49 (0)30 9489 2422
Email:  office(at)eu-openscreen.eu
Web:   www.eu-openscreen.eu


EU-OPENSCREEN ERIC
Robert-Rössle-Str. 10, Building C87
13125 Berlin, Germany
 

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