Department of Biochemistry and Biophysics

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  • Molecular structure creates new possibilities to combat antibiotic resistance 2021-01-15 New research, funded by the Swedish research council and the Knut and Alice Wallenberg Foundation (KAW), has revealed for the first time a large fully intact component of the lipopolysaccharide (LPS) biosynthesis machinery in Gram-negative bacteria. This new structure from the model organism E. coli provides a structural context to over a decade’s worth of previous biochemical studies and creates new possibilities in the development of novel therapies to combat the growing global problem of infections due to antibiotic-resistant bacteria. The study is published in the scientific journal Nature Communications.
  • Scientists show how a molecular machine works to regulate our cell’s internal pH and sodium levels 2020-10-28 Scientists at Stockholm University in Stockholm have established a mechanism by which our cells fine-tune their internal pH and sodium levels. Using cryo electron microscopy they have determined the first 3D-structure of a so-called “sodium/proton exchanger” that carries out this task. Ever since the discovery of these transport machines by Peter Mitchell in the 1970s we finally have a molecular picture of this fundamental process carried out in most, if not all, cells. Their findings could help in the development of anticancer drugs in particular.
  • Structural basis of mitochondrial translation 2020-10-16 Researchers from DBB have been able to provide functional details about the mitochondrial translation by analyzing mitoribosomes with bound messenger and transfer RNA, and nascent polypeptide. The two studies, published in eLife and Nature Communications, reveal new mitoribosomal components and suggest how the expression of our genetic information is coordinated in mitochondria.
  • Molecular structure of mammalian mitochondrial complex I reveals substrate reduction principles 2020-10-16 The respiratory complex I is a gigantic redox-driven proton pump that initiates cellular respiration in mitochondria — the powerplants of our cells. Moreover, dysfunction of complex I has been linked to half of all human mitochondrial disorders, but the molecular mechanism remains one of the most puzzling unsolved questions of bioenergetics.
  • SciLifeLab researchers contribute to interactive 3D COVID-19 exhibition 2020-10-09 SciLifeLab Fellow Alexey Amunts (Stockholm University) and his team have been collecting and interpreting newly available cryo-EM datasets to be used in a virtual interactive 3D exhibition about COVID-19. The datasets were dissected into different levels of information and sent to Interspectral AB, the company who then creates the 3D presentation. The goal is to facilitate communication of complex data to the public in an attractive and educative way.
  • Wallenberg grant for research on aggression 2020-09-30 How is aggression controlled in the brain and what methods can we use to influence it? These are some of the questions that Christian Broberger, professor of neurochemistry, hopes to get answers to during a five-year project that now receives SEK 20.4 million from the Knut and Alice Wallenberg Foundation.