Department of Biochemistry and Biophysics

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  • Decision due to the new coronavirus on planning teaching and examinations Spring-21 2021-01-21 Teaching and examination at Stockholm University will continue to be conducted mainly digitally during the spring term 2021 and until further notice in line with the guidelines that applied during the latter part of the autumn term 2020. This continues to mean that teaching that require physical attendance may not gather more than eight people, and that no hall exams are given. Detailed planning for the teaching during the spring term is done by the departments.
  • “Being on the Nobel Committee is probably one of the best things you can do as a Swedish researcher” 2021-01-21 Gunnar von Heijne is one of Sweden’s most cited researchers in the field of biochemistry and is known for his research on membrane proteins. He has also been a member and chairman of the Nobel Committee for chemistry. But it all started with an enthusiastic chemistry teacher in high school.
  • Bioenergetics: New features of ATP synthase 2021-01-18 An intricate organisation of the ATP synthase in mitochondria is reported in two cryo-EM studies that illuminate the structural basis for its oligomerisation.
  • Molecular structure creates new possibilities to combat antibiotic resistance 2021-01-18 New research, funded by the Swedish research council and the Knut and Alice Wallenberg Foundation (KAW), has revealed for the first time a large fully intact component of the lipopolysaccharide (LPS) biosynthesis machinery in Gram-negative bacteria. This new structure from the model organism E. coli provides a structural context to over a decade’s worth of previous biochemical studies and creates new possibilities in the development of novel therapies to combat the growing global problem of infections due to antibiotic-resistant bacteria. The study is published in the scientific journal Nature Communications.
  • Scientists show how a molecular machine works to regulate our cell’s internal pH and sodium levels 2020-10-28 Scientists at Stockholm University in Stockholm have established a mechanism by which our cells fine-tune their internal pH and sodium levels. Using cryo electron microscopy they have determined the first 3D-structure of a so-called “sodium/proton exchanger” that carries out this task. Ever since the discovery of these transport machines by Peter Mitchell in the 1970s we finally have a molecular picture of this fundamental process carried out in most, if not all, cells. Their findings could help in the development of anticancer drugs in particular.
  • Structural basis of mitochondrial translation 2020-10-16 Researchers from DBB have been able to provide functional details about the mitochondrial translation by analyzing mitoribosomes with bound messenger and transfer RNA, and nascent polypeptide. The two studies, published in eLife and Nature Communications, reveal new mitoribosomal components and suggest how the expression of our genetic information is coordinated in mitochondria.