Department of Biochemistry and Biophysics

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  • Structural basis of mitochondrial translation 2020-10-16 Researchers from DBB have been able to provide functional details about the mitochondrial translation by analyzing mitoribosomes with bound messenger and transfer RNA, and nascent polypeptide. The two studies, published in eLife and Nature Communications, reveal new mitoribosomal components and suggest how the expression of our genetic information is coordinated in mitochondria.
  • Molecular structure of mammalian mitochondrial complex I reveals substrate reduction principles 2020-10-16 The respiratory complex I is a gigantic redox-driven proton pump that initiates cellular respiration in mitochondria — the powerplants of our cells. Moreover, dysfunction of complex I has been linked to half of all human mitochondrial disorders, but the molecular mechanism remains one of the most puzzling unsolved questions of bioenergetics.
  • SciLifeLab researchers contribute to interactive 3D COVID-19 exhibition 2020-10-09 SciLifeLab Fellow Alexey Amunts (Stockholm University) and his team have been collecting and interpreting newly available cryo-EM datasets to be used in a virtual interactive 3D exhibition about COVID-19. The datasets were dissected into different levels of information and sent to Interspectral AB, the company who then creates the 3D presentation. The goal is to facilitate communication of complex data to the public in an attractive and educative way.
  • Wallenberg grant for research on aggression 2020-09-30 How is aggression controlled in the brain and what methods can we use to influence it? These are some of the questions that Christian Broberger, professor of neurochemistry, hopes to get answers to during a five-year project that now receives SEK 20.4 million from the Knut and Alice Wallenberg Foundation.
  • A roadmap for gene expression in mitochondria 2020-09-02 A new study from the Department of Biochemistry and Biophysics reveals the molecular connectivity of processes implicated in the synthesis of proteins within mitochondria. The study is published in the scientific journal Molecular Cell.
  • A ribosome odyssey in mitochondria 2020-08-31 The ciliate mitoribosome structure provides new insights into the diversity of translation and its evolution.