Molecular basis for the variability of mitoribosomes revealed
2019-02-14
Mitochondrial ribosomes are known to be highly variable across species, but the molecular basis for this phenomenon was not known. The analysis published in Molecular Biology and Evolution uncover a fundamental evolutionary mechanism that drives the increasing diversity. The interdisciplinary study was led by Alexey Amunts in collaboration with researchers from Georgia Institute of Technology and Harvard Medical School.
An engineered botulinum toxin with improved medicinal potential
2019-01-17
The botulinum neurotoxin is a common medicine for the treatment of a wide range of neuromuscular disorders, including muscle spasms, overactive bladder, cervical dystonia, and cerebral palsy (CP), as well as chronic migraine, and hyper-sweating. A team from Stockholm University, in collaboration with Ipsen Bioinnovation and Harvard Medical School, has now determined the molecular details of why a botulinum toxin variant, that they have designed, has enhanced receptor-binding properties. This engineered toxin shows great promise as a drug candidate.
David Drew receives ERC Consolidator Grant
2018-12-17
David Drew at the Department of Biochemistry and Biophysics, Stockholm University, has been awarded an ERC Consolidator Grant. He and his team will study how the cell maintains a healthy working environment. The aim of the research is to establish how a family of proteins required for transporting nutrients and ions in and out of the cell are being turned on-and-off. The outcome is likely to bring us closer to understanding the role of these transporting machines in the human body for the benefit of human health.
Nobel Laureate in Chemistry visited Stockholm University
2018-12-11
George P. Smith, one of the Nobel Laureates in Chemistry 2018, visited Stockholm University and the Department of Biochemistry and Biophysics. He held a lecture for PhD students and answered questions about his research and how his interest in chemistry began.
Structure reveals new routes to target tuberculosis
2018-12-06
New research has revealed the structure of a large respiratory complex from a closely related species of the deadly human pathogen Mycobacterium tuberculosis, which infects the lungs. This new structure provides many routes to develop novel therapies to combat this deadly disease. The study is published in the scientific journal Nature Structural and Molecular Biology.
Accumulation of undegraded peptides in mitochondria and chloroplasts conveys toxic signals
2018-11-20
Researchers from Stockholm University in collaboration with scientists from La Trobe University in Melbourne, University of Western Australia in Perth and Karolinska Institute discovered that accumulation of undegraded peptides in mitochondria and chloroplasts as a result of lack of the organellar peptidases triggers the activation of the classical plant defense response in the absence of a pathogen.
Molecular basis for the variability of mitoribosomes revealed
2019-02-14
Mitochondrial ribosomes are known to be highly variable across species, but the molecular basis for this phenomenon was not known. The analysis published in Molecular Biology and Evolution uncover a fundamental evolutionary mechanism that drives the increasing diversity. The interdisciplinary study was led by Alexey Amunts in collaboration with researchers from Georgia Institute of Technology and Harvard Medical School.
An engineered botulinum toxin with improved medicinal potential
2019-01-17
The botulinum neurotoxin is a common medicine for the treatment of a wide range of neuromuscular disorders, including muscle spasms, overactive bladder, cervical dystonia, and cerebral palsy (CP), as well as chronic migraine, and hyper-sweating. A team from Stockholm University, in collaboration with Ipsen Bioinnovation and Harvard Medical School, has now determined the molecular details of why a botulinum toxin variant, that they have designed, has enhanced receptor-binding properties. This engineered toxin shows great promise as a drug candidate.
David Drew receives ERC Consolidator Grant
2018-12-17
David Drew at the Department of Biochemistry and Biophysics, Stockholm University, has been awarded an ERC Consolidator Grant. He and his team will study how the cell maintains a healthy working environment. The aim of the research is to establish how a family of proteins required for transporting nutrients and ions in and out of the cell are being turned on-and-off. The outcome is likely to bring us closer to understanding the role of these transporting machines in the human body for the benefit of human health.
Nobel Laureate in Chemistry visited Stockholm University
2018-12-11
George P. Smith, one of the Nobel Laureates in Chemistry 2018, visited Stockholm University and the Department of Biochemistry and Biophysics. He held a lecture for PhD students and answered questions about his research and how his interest in chemistry began.
Structure reveals new routes to target tuberculosis
2018-12-06
New research has revealed the structure of a large respiratory complex from a closely related species of the deadly human pathogen Mycobacterium tuberculosis, which infects the lungs. This new structure provides many routes to develop novel therapies to combat this deadly disease. The study is published in the scientific journal Nature Structural and Molecular Biology.
Accumulation of undegraded peptides in mitochondria and chloroplasts conveys toxic signals
2018-11-20
Researchers from Stockholm University in collaboration with scientists from La Trobe University in Melbourne, University of Western Australia in Perth and Karolinska Institute discovered that accumulation of undegraded peptides in mitochondria and chloroplasts as a result of lack of the organellar peptidases triggers the activation of the classical plant defense response in the absence of a pathogen.
