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  2. Stockholm University
  3. Department of Biochemistry and Biophysics
  4. Research
  5. David Drew

David Drew

Researcher

Phone: +46 8 16 2295

E-mail:

Room: A 553


Structure and Mechanism of Solute Carrier (SLC) Transporters


Secondary transporters are the targets for many therapeutics and they often play a major role in drug pharmacokinetics. Understanding the mechanisms by which secondary transporters shuttle and move ions, drugs, and natural compounds across membranes is of fundamental importance. Because of the technical difficulties in working with membrane proteins our structural understanding is very limited. The goal of my research is to investigate the alternating access-mechanism of solute transporters which are critical to cell homeostasis and their dysfunction is associated with human diseases, such as cancer and cardiovascular heart disease. To achieve this we combine crystal structures with biochemical and biophysical techniques. These goals are facilitated by the development of novel methods in membrane protein overexpression, purification and crystallization.


Selected Publications

  • Lee C, Kang HJ, von Ballmoos C, Newstead S, Uzdavinys P, Dotson D, Iwata S, Beckstein O, Cameron A.D, Drew D (2013)
    A two-domain elevator mechanism for sodium/proton antiport.
    Nature. Sept;1
  • Hu NJ, Iwata S, Cameron AD, Drew D (2011)
    Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.
    Nature. Oct;3:478:408-11.
  • Sonoda Y, Newstead S, Hu N, Alguel Y, l Nji E, Beis K, Yashiro S, Lee C, Leung J, Cameron A.D, Byrne B, Iwata S, Drew D (2011).
    Benchmarking membrane protein thermostability for improving throughput of high-resolution X-ray structures.
    Structure. Jan 12;19(1):17-25.
  • Newstead, S., Kim H, von Heijne G, Iwata S, Drew D (2007)
    High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in S. cerevisiae
    Proc Natl Acad Sci U S A. Aug 28;104 (35):13936-41.

Click "Publications" in the menu to the right to see the most recent publications.


Funding Sources

EMBO young investigator program
Swedish Research council
The Knut and Alice Wallenberg Foundation
The Wenner-Gren Foundation.

Groupmembers


Saba Abdul Hussein

Postdoc

+46 8 674 7979
A557

Mathieu Coincon

Postdoc

+46 8 674 7979
A 557

Emmanuel Nji

Postdoc

+46 8 674 7979
A 557

Abdul Aziz Qureshi

PhD Student

+46 8 16 3301
A555

Povilas Uzdavinys

PhD Student

+46 8 16 3301
A555

Iven Winkelmann

PhD Student

+46 8 674 7979
A557

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